StemTek Therapeutics, a leading Spanish biotech start up, today announced the availability of Cell2Sphere, an innovative 3D cell culture kit created specifically for use in cancer stem cell research, pharmaceutical drug development and personalized medicine. Cell2Sphere frozen spheroid tissue culture samples increase the shelf life of today’s 3D cultures, enhancing the biological relevance of pre-clinical in vitro 3D culture efficacy assays.
Cell2Sphere is a scalable solution for High-throughput screening (HTS) and detection of phenotypic or genetic changes in cancer stem cells. By more closely resembling the natural environment of tumor cells, Cell2Sphere enriched 3D spheroids allow for more comprehensive, accurate, and reproducible data for in vitro to in vivo predictions in the search for therapeutic compounds and designer molecules to stop cancer.
“The Cell2Sphere 3D kit has allowed us to achieve results that wouldn’t have been possible with our on-site tissue culture program alone. We have saved weeks of hard work while also being able to focus on data mining large amounts of statistically sound data sets,” said Dr. Javier A. Menendez, co-founder and chairman of Metabostem, a biopharmaceutical company that develops breakthrough oncology drugs directed at the unique metabolic features of cancer stem cells (CSC). “We’ve been waiting for an innovative, easy-to-use CSC-based platform to let us focus on drug screening rather than on time-consuming technical issues. Without requiring additional skills, we can now easily design results-based testing, streamline budgeting and improve planning with this kit.”
Using a patented scaffold-free technology, Cell2Sphere tumor spheroid cells arrive frozen and grow in a standard 96 well ultra low-adhesion plate. Developed by molecular and cellular oncology specialists at Stemtek Therapeutics, Cell2Sphere is the result of rigorous analysis to push the boundaries in early stage drug screening to develop new anticancer therapies.
According to Angel Garcia Martin, CEO of StemTek Therapeutics, “Only about 10 percent of compounds progress successfully through clinical development. Many drugs fail during clinical trials, especially during phase III, which is the most expensive phase of development, largely due to the lack of clinical efficacy or unacceptable toxicity. As researchers we understand that 3D spheroid tissue culture is more accurate but a notoriously time and labor intensive process, so we created a universal solution to solve this. Much like DNA kits have saved labs many hours in time intensive tasks, we believe 3D spheroid tissue culture will become mainstream allowing researchers to dedicate less time to growing tissue samples and spend more time better understanding cancer cell biology. So we can stop reinventing the wheel and focus on finding a cure.”